Our lab studies how genetic and environmental factors intersect to influence cancer risk.
In particular we are interested in understanding how acquired mutations in the blood (clonal hematopoiesis) lead to hematologic malignancies and what we can do to prevent this.
Cancer is caused by a complex interaction between inherited genetics, acquired somatic mutations and environmental factors. We use computational and experimental methods to study this and to identify avenues of prevention and early intervention. While a large focus of our work is on hematologic cancers we have a broader interest in susceptibility to cancer and mosaicism.
We don’t just study cancer. We lead clinical trials where we are trying to prevent the development of cancer. We also use the data from these studies to better understand who is benefiting the most from these interventions and how we can improve them.
